CASE STUDY!Brian Wilson is an 18-year-old male student who was healthy until two days ago when he ex

CASE STUDY!Brian Wilson is an 18-year-old male student who was healthy until two days ago when he experienced severe abdominal pain, fever, and vomiting. A visit to his GP revealed that he had acute appendicitis. Brian is in excellent health but during the surgery, his body temperature began to rise quite quickly. Medical staff managed this emergency and later diagnosed a genetic condition called Malignant Hyperthermia (MH) that causes a rapid rise in core body temperature, severe muscle contractions and respiratory distress under general anaesthesia (with Halothane).During Brian’s sedation, Halothane anesthetic caused an adverse effect by binding with Brian’s variant RyR1 ryanodine receptor located in his skeletal muscle cells. At what location in Q2 did this occur? Explain what happened at the molecular level that caused the severe muscle contractions. (4 marks)Discuss the impact of the hypermetabolic state on chemical demands and adjustments to metabolism in Brian’s skeletal muscle cells ?Explain what “hypermetabolic†means. (1 mark) How does ATP contribute to maintaining calcium concentration gradients in muscles? (1.5 marks)

 

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